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Rizatriptan Orodispersible Tablets
Rizatriptan orodispersible tablets are a melt in the mouth tablet solution for migraines with or without aura. Rizatriptan belongs to a group of medicines called the ‘Triptans’, They are particular good at helping people who suffer with nausea and sickness during a migraine as it avoids having to swallow the tablet.
Triptans act on the 5HT1B/1D receptors in the brain. They contract (tighten) blood vessels a particular part of the brain back to their normal state. This reduces pressure in that area and relieves the symptoms of migraine headache.
What is it used for?
Rizatriptan orodispersible is a medication used for the treatment of headaches associated with migraines with or without aura. Aura is the term used to describe the neurological side effects usually linked to migraines such as light sensitivity, visual field disturbances and nausea to name a few. Rizatriptan belongs to a group of medicines called the ‘Triptans’, it’s also more technically known as a 5HT1B/1D receptor agonist. (NHS)
How does it work?
As mentioned above Rizatriptan orodispersible acts on the 5HT1B/1D receptors in the brain. During a migraine headache blood vessels in and around the brain become dilated. This dilation attributes to inflammation on sensitive tissues around that area, and on the trigeminal sensory nerves leading to pain. Rizatriptan contracts these vessels back to their normal state so that pressure is reduced leading to relieved symptoms.
How is Rizatriptan orodispersible taken?
Rizatriptan orodispersible should be taken as soon as possible after the onset of a migraine, whether you are experiencing aura or not. One tablet is usually sufficient to treat a migraine. If the headache comes back after the first has been treated a further tablet can be taken providing this is at least 2 hours after the first dose. So a further tablet can be taken for a NEW attack as long as it’s taken 2 hours after the first tablet. No more than 2 should be taken in any 24 hour period.
If however you do not experience symptomatic relief from the first dose it is not recommended to take a second dose for the same episode of migraine. At this stage you can use painkillers to help control the symptoms – please see below.
This tablet will be different to most in that it is not made to be swallowed, instead it is to be placed on the tongue where it will be dissolved and then be swallowed with the saliva. Therefore this tablet does not need to be taken with water, it helps in situations where nausea and vomiting can occur due to taking medicines with water. You should ideally take this medication on an empty stomach, as taking it with food or in a fed state can delay action by an hour.
How long does it take to work?
Rizatriptan orodispersible can work as quick as 30 minutes after taking, as mentioned above this is in the absence of food, so best taken on an empty stomach. Please remember that if you don’t have any improvement after 2 hours then proceed with using painkillers.
Can I take painkillers with Rizatriptan orodispersible?
Yes, if your first dose of Rizatriptan orodispersible has not sufficiently controlled your migraine you can take aspirin, paracetamol or any other NSAIDs such as Ibuprofen. You can take painkillers along with Rizatriptan Orodispersible in the first instance if you need to. If you are on any other painkillers and are unsure please contact us first HERE.
How to use for migraine:- Take ONE Rizatriptan 10mg OD tablet as soon as possible after your migraine headache has started. Do not use it to prevent an attack.
The usual dose is 10 mg.
If migraine returns within 24 hours
In some patients, migraine symptoms can return within a 24-hour period. If your migraine does return you can take an additional dose of Rizatriptan. You should always wait at least 2 hours between doses.
If after 2 hours you still have a migraine
If you do not respond to the first dose of Rizatriptan during an attack, you should not take a second dose of Rizatriptan for treatment of the same attack. It is still likely, however, that you will respond to Rizatriptan during the next attack.
Do not take more than 2 doses of Rizatriptan in a 24-hour period, (for example, do not take more than two 10-mg or 5 mg orodispersible tablets or tablets in a 24-hour period). You should always wait at least 2 hours between doses.
If your condition worsens, seek medical attention.
How to administer Rizatriptan orodispersible tablets
- Rizatriptan orodispersible tablets dissolves in the mouth.
- Open the blister pack with dry hands.
- The orodispersible tablets should be placed on your tongue, where it dissolves and can be swallowed with the saliva.
- The orodispersible tablets can be used in situations in which liquids are not available, or to avoid the nausea and vomiting that may accompany the ingestion of tablets with liquids.
- Rizatriptan is also available as a tablet to be taken with liquids.
If you take more Rizatriptan than you should
If you take more Rizatriptan than you should, talk to your doctor or pharmacist straight away. Take the medicine pack with you.
Signs of over-dosage can include dizziness, drowsiness, vomiting, fainting and slow heart rate.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Like all medicines, this medicine can cause side effects, although not everybody gets them.
In adult studies, the most common side effects reported were dizziness, sleepiness and tiredness.
Common (may affect up to 1 in 10 people)
- tingling (paraesthesia), headache, decreased sensitivity of skin (hypoaesthesia), decreased mental sharpness, tremor,
- fast or irregular heart beat (palpitation), very fast heartbeat (tachycardia),
- flushing (redness of the face lasting a short time), hot flushes, sweating,
- throat discomfort, difficulty breathing (dyspnoea),
- feeling sick (nausea), dry mouth, vomiting, diarrhoea,
- feeling of heaviness in parts of the body,
- pain in abdomen or chest
Uncommon (may affect up to 1 in 100 people)
- unsteadiness when walking (ataxia), dizziness (vertigo), blurred, vision,
- confusion, insomnia, nervousness,
- high blood pressure (hypertension); thirst, indigestion (dyspepsia),
- itching and lumpy rash (hives), allergic reaction (hypersensitivity); swelling of the face, lips, tongue and/or throat which may cause difficulty breathing and/or swallowing (angioedema)
- neck pain, feeling of tightness in parts of the body, stiffness, muscle weakness
For a full list of side effects CLICK HERE
Tell your doctor right away if you have symptoms of allergic reactions, serotonin syndrome, heart attack or stroke.
In addition, tell your doctor if you experience any symptoms that suggest an allergic reaction (such as a rash or itching) after taking Rizatriptan.
If you get any side effects, talk to your doctor or pharmacist.
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