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Zolmitriptan Orodispersible Tablets

Zolmitriptan orodispersible tablets are melt in the mouth tablets that belong to the selective serotonin 5-HT1B / 1D receptor agonist class of drugs, also known as "triptans".

When taken at the onset of a migraine, triptans are very effective in stopping a migraine headache from reaching its full intensity.

The orodispersible tablets are particularly helpful in patients who experience migraines along with nausea and vomitting. They melt in the mouth and patients are less likely to feel nausea or vomit after using them.


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What is it used for?

Zolmitriptan Orodispersible is used for the management of migraine attacks with or without aura. Aura for those who don’t know are the neurological effects (nausea, light sensitivity etc…) which can be experienced by some sufferers, typically it can affect up to 1 in 5 migraines sufferers. Zolmitriptan Orodispersible belongs to a group of medicine called the ‘triptans’ it is a 5HT1B/1D receptor agonist. (migraine.org.uk)

How does it work?

Zolmitriptan Orodispersible works as a selective agonist for the 5-HTIB/1D receptors leading to the contraction of vessels around the brain. When these vessels are dilated (during a migraine attack) they cause symptoms of the migraine to kick in such as headaches, aura, nausea and vomiting. (NHS)

How is Zolmitriptan Orodispersible taken?

This medicine is only taken on a when required basis, it is not to be used in a prophylaxis manner. This means that it doesn’t prevent migraines from occurring it only helps stop them once you have one.

This tablet will be different to most in that it is not made to be swallowed, instead it is to be placed on the tongue where it will be dissolved and then be swallowed with the saliva. Therefore this tablet does not need to be taken with water, it helps in situations where nausea and vomiting can occur due to taking medicines with water. This medicine can be taken with or without food.

Zolmitriptan Orodispersible should be taken as soon as possible after a migraine attack, you will need to take only one tablet to begin with. A secondary tablet may be taken if the migraine continues however you must remember that it cannot be taken within 2 hours of the first dose. No more than 2 tablets should be taken in any 24 hour period. If no symptom relief is achieved after 2 doses then you can combine with other painkillers – see below.

How long does it take to work?

This medication usually takes up to an hour to work in the majority of patients, the clinical effectiveness of the medicine will remain for up to 4-5 hours after taking the tablet.

Can I take painkillers with Zolmitriptan Orodispersible?

You can take aspirin, paracetamol or ibuprofen alongside Zolmitriptan Orodispersible. Using painkillers alongside this migraine treatment can work better than using Zolmitriptan alone. If you want more clarification on other pain killers then please get in touch and we’ll be happy to help.

B.V. 2019

Usual Dose for migraine: One Tablet to be dispersed in the mouth at the onset (beginning) of a Migraine. Do not use to prevent migraine. 

The usual starting dose is 2.5mg of zolmitriptan.

If a 2.5mg dose did not give you enough help with your migraine then the dose can be increased to 5mg.

The maximum daily dose is 10mg zolmitriptan.

Taking this medicine

Place the tablet on your tongue, where it will dissolve and be swallowed with the saliva. You do not have to take a drink of water in order to swallow your tablet
You can take Zolmitriptan with or without food. It does not affect the way that Zolmitriptan works.
If after 2 hours after taking Zolmitriptan you still have migraine or migraine returns within 24 hours you can take another tablet

Do not take more than 2 doses of Zolmitriptan in a 24-hour period.

Always wait at least 2 hours between doses.

If your condition worsens, seek medical attention.

If you take more tablets than you should or someone accidentally swallows some, contact your doctor or go to the nearest hospital straight away. Take the medicine pack and any remaining tablets with you so that the doctor knows what has been taken.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Like all medicines, this medicine can cause side effects, although not everybody gets them. Some of the symptoms below could be part of the migraine attack itself.

If you experience any of the side effects listed below stop taking the medication and seek the doctor immediately

common: may affect up to 1 in 10 people

  • These side effects are usually mild and go away after a short time.
  • Abnormal sensations such as tingling in your fingers and toes or skin that is sensitive to touch.
  • Feeling sleepy, dizzy or warm.
  • Headache.
  • Uneven heart beat.
  • Feeling sick (nausea) or being sick (vomiting).
  • Stomach pain.
  • Dry mouth.
  • Muscle weakness or muscle pain.
  • Feeling weak.
  • Heaviness, tightness, pain or pressure in the throat, neck, arms and legs, or chest.
  • Difficulty in swallowing (dysphagia).
  • uncommon: may affect up to 1 in 100 people
  • Very fast heart beat.
  • Slightly higher blood pressure.
  • Increase in the amount of water you pass (urine) or in how often you need to pass water.

For a full list of side effects CLICK HERE

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse.


Always read the patient information leaflet before commencing treatment.
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