Like all medicines, this medicine can cause side effects, although not everybody gets them.
STOP TAKING the medicine and tell your doctor if you experience:
- heartburn, indigestion
- signs of intestinal bleeding (severe stomach pain, or other abnormal stomach symptoms, vomiting blood or liquid with what looks like coffee granules, blood in the stools/motions, black tarry stools)
- signs of inflammation of the brain lining such as: stiff neck, headache, feeling or being sick, fever or feeling disorientated
- signs of a severe allergic reaction (swelling of the face, tongue or throat, difficult breathing, worsening of asthma).
- severe skin reactions such as blistering and peeling of the skin
- high blood pressure, water retention
- liver problems (causing yellowing of the skin and white of eyes)
- kidney problems (causing increased or decreased urination, swelling of the legs)
- heart failure (causing breathlessness, swelling)
- severe skin reaction known as DRESS syndrome (frequency not known). Symptoms of DRESS include: skin rash, fever, swelling of lymph nodes and an increase of eosinophils (a type of white blood cells).
- A red, scaly widespread rash with bumps under the skin and blisters mainly localised on the skin folds, trunk, and upper extremities accompanied by fever at the initiation of treatment (acute generalised exanthematous pustulosis) (frequency not known). See also section 2.
- Skin becomes sensitive to light (frequency not known).
Other possible side effects:
Common may affect up to 1 in 10 people:
- stomach pain or discomfort, feeling or being sick, diarrhoea
- higher levels of liver enzymes (shown in blood tests)
- change in kidney function (shown in blood tests)
- excessive sweating
Uncommon may affect up to 1 in 100 people:
- headache and dizziness, wind and constipation, skin rashes, swelling of the face, itching.
- reduction in red blood cells number or increase in platelets (blood clotting cells)
- Very rare may affect up to 1 in 10,000 people:
- reduction in blood cells (causing sore throat, mouth ulcers, flu-like symptoms, severe exhaustion, unexplained bleeding, bruising and nosebleeds. Stop taking this medicine and contact a doctor at once if this occurs)
- visual disturbances, ringing in the ears, spinning sensation
- confusion, depression, hallucinations
- fatigue, drowsiness, generally feeling unwell
- mouth ulcer
- inflammation of the pancreas
- worsening of ulcerative colitis and Crohn’s disease
- ‘pins and needles’ e.g. pricking, tingling, burning or numbing sensation
- inflammation of the optic nerve, sensitivity to light
Medicines such as this medicine may be associated with a small increased risk of heart attack ("myocardial infarction") or stroke. (See section 2) Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects, you can help provide more information on the safety of this medicine.
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